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Capturing the complexity of human strategic decision-making with machine learning – Nature

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Nature Human Behaviour (2025)
Strategic decision-making is a crucial component of human interaction. Here we conduct a large-scale study of strategic decision-making in the context of initial play in two-player matrix games, analysing over 90,000 human decisions across more than 2,400 procedurally generated games that span a much wider space than previous datasets. We show that a deep neural network trained on this dataset predicts human choices with greater accuracy than leading theories of strategic behaviour, revealing systematic variation unexplained by existing models. By modifying this network, we develop an interpretable behavioural model that uncovers key insights: individuals’ abilities to respond optimally and reason about others’ actions are highly context dependent, influenced by the complexity of the game matrices. Our findings illustrate the potential of machine learning as a tool for generating new theoretical insights into complex human behaviours.
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The datasets generated and/or analysed are available at https://osf.io/xrvaw.
The code used to generate the results is available at https://osf.io/xrvaw.
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This work and related results were made possible with the support of the NOMIS Foundation. We thank N. Chater and S. Li for helpful discussions.
Department of Computer Science, Princeton University, Princeton, NJ, USA
Jian-Qiao Zhu & Thomas L. Griffiths
Faculty of Computing and Data Science, Boston University, Boston, MA, USA
Joshua C. Peterson
Department of Economics, Harvard University, Cambridge, MA, USA
Benjamin Enke
National Bureau of Economic Research, Cambridge, MA, USA
Benjamin Enke
Department of Psychology, Princeton University, Princeton, NJ, USA
Thomas L. Griffiths
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J.-Q.Z.: conceptualization, methodology, investigation, formal analysis, data curation, software, visualization, writing (original draft), and writing (reviewing and editing); J.C.P.: methodology, formal analysis, software, visualization, and writing (reviewing and editing); B.E.: conceptualization, methodology, formal analysis, supervision, validation, and writing (reviewing and editing); T.L.G.: conceptualization, methodology, formal analysis, supervision, validation, writing (reviewing and editing), resources, and funding acquisition.
Correspondence to Jian-Qiao Zhu.
The authors declare no competing interests.
Nature Human Behaviour thanks James (R) Bland and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Peer reviewer reports are available.
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Supplementary Sections A–F, Figs. 1–7, Tables 1–5 and References.
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Zhu, JQ., Peterson, J.C., Enke, B. et al. Capturing the complexity of human strategic decision-making with machine learning. Nat Hum Behav (2025). https://doi.org/10.1038/s41562-025-02230-5
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DOI: https://doi.org/10.1038/s41562-025-02230-5
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